Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS

The pleiotropic two-component regulatory system PhoP-PhoQ.

Stereochemical Trajectories of a Two-Component Regulatory System PmrA/B in a Colistin-Resistant Acinetobacter baumannii Clinical Isolate

Background: There is limited information on the 3D prediction and modeling of the colistin resistance-associated proteins PmrA/B TCS in Acinetobacter baumannii. We aimed to evaluate the stereochemical structure and domain characterization of PmrA/B in an A. baumannii isolate resistant to high-level colistin, using bioinformatics tools. Methods: The species of the isolate and its susceptibility ...

Component and protein domain exchange analysis of a thermoresponsive, two-component regulatory system of Pseudomonas syringae.

Two closely related phytopathogenic bacterial strains, Pseudomonas syringae pv. glycinea PG4180 and P. syringae pv. tomato DC3000, produce the chlorosis-inducing phytotoxin coronatine (COR) in a remarkably divergent manner. PG4180 produces COR at the virulence-promoting temperature of 18 degrees C, but not at 28 degrees C. In contrast, temperature has no effect on COR synthesis in DC3000. A mod...

Histamine in two component system-mediated bacterial signaling.

Histamine is a key mediator governing vital cellular processes in mammals beyond its decisive role in inflammation. Recent evidence implies additional actions in both eukaryotes and prokaryotes. Besides its function in host defense against bacterial infections, histamine elicits largely undefined actions in microorganisms that may contribute to bacteria-host interactions. Bacterial proliferatio...

Bacterial two-component systems share a common mechanism to regulate signaling and specificity

Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 1 BACTERIAL TWO-COMPONENT SYSTEMS SHARE A COMMON MECHANISM TO REGULATE SIGNALING AND SPECIFICITY